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Title: The Future of Migraine Treatment: What Drugs Are on the Horizon? [Print This Page]

Author: medicarest Time: 3/21/2025 17:50
Title: The Future of Migraine Treatment: What Drugs Are on the Horizon?

Migraine drugs fall into two main categories: those that treat acute migraine attacks and those that prevent them. Here's a breakdown:

Acute Migraine Medications(Abortive Medications):

Pain Relievers:
- Over-the-counter (OTC) pain relievers: These include NSAIDs like ibuprofen and naproxen, and medications like acetaminophen. They can be effective for mild to moderate migraines. Combination medications containing caffeine, aspirin, and acetaminophen (like Excedrin Migraine) are also available.
- Prescription pain relievers: If OTC medications aren't effective, doctors may prescribe stronger pain relievers. However, overuse can lead to medication-overuse headaches.

Triptans:
- These prescription drugs, such as sumatriptan (Imitrex) and rizatriptan (Maxalt), work by constricting blood vessels and blocking pain pathways in the brain. They are often very effective for moderate to severe migraines.
CGRP Inhibitors (Gepants):
- These newer prescription drugs, like ubrogepant (Ubrelvy) and rimegepant (Nurtec ODT), block the activity of calcitonin gene-related peptide (CGRP), a molecule involved in migraine pain.
- Intranasal zavegepant (Zavzpret): This is a nasal spray gepant, that delivers fast acting relief.
Ditans:
- Lasmiditan (Reyvow) is a ditan, that also works on serotonin receptors, but in a different way than triptans.
Anti-nausea Medications:
- Migraines are often accompanied by nausea and vomiting. Anti-nausea medications, such as metoclopramide (Reglan) or prochlorperazine (Compazine), can help alleviate these symptoms.

Preventive Migraine Medications:

Beta-blockers:
- These medications, such as propranolol (Inderal), are commonly used to treat high blood pressure, but they can also help prevent migraines.
Antidepressants:
- Tricyclic antidepressants, such as amitriptyline, and serotonin-norepinephrine reuptake inhibitors (SNRIs), such as venlafaxine, can be effective in preventing migraines.
Anti-seizure Medications:
- Certain anti-seizure medications, such as topiramate (Topamax) and valproate, can also help prevent migraines.
CGRP Monoclonal Antibodies:
- These injectable medications, such as erenumab (Aimovig), fremanezumab (Ajovy), and galcanezumab (Emgality), block the activity of CGRP or its receptor.
Botox Injections:
- Botulinum toxin type A (Botox) injections can be used to prevent chronic migraines.

Important Considerations:

It's crucial to consult with a healthcare professional to determine the most appropriate migraine medication for your individual needs.
Overuse of pain relievers can lead to medication-overuse headaches.
Migraine medications can have side effects, so it's essential to discuss potential risks with your doctor.
There are many different types of migraines, and what works for one person, may not work for another. So patience is needed when working with a doctor to find the right treatment.
Lifestyle changes, such as stress management, regular exercise, and avoiding migraine triggers, can also play a significant role in migraine management.

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